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[L-CARNITINA] Carnitina ed Upregulation dei recettori androgeni

 

 

Medicine & Science in Sports & Exercise:
July 2006 – Volume 38 – Issue 7 – pp 1288-1296
doi: 10.1249/01.mss.0000227314.85728.35
BASIC SCIENCES: Original Investigations

Androgenic Responses to Resistance Exercise: Effects of Feeding and L-Carnitine
KRAEMER, WILLIAM J.; SPIERING, BARRY A.; VOLEK, JEFF S.; RATAMESS, NICHOLAS A.; SHARMAN, MATTHEW J.; RUBIN, MARTYN R.; FRENCH, DUNCAN N.; SILVESTRE, RICARDO; HATFIELD, DISA L.; VAN HEEST, JACI L.; VINGREN, JAKOB L.; JUDELSON, DANIEL A.; DESCHENES, MICHAEL R.; MARESH, CARL M.

Abstract

Purpose: The purpose of this investigation was to determine the effects of 3 wk of L-carnitine L-tartrate (LCLT) supplementation and post-resistance-exercise (RE) feeding on hormonal and androgen receptor (AR) responses.

Methods: Ten resistance-trained men (mean ± SD: age, 22 ± 1 yr; mass, 86.3 ± 15.3 kg; height, 181 ± 11 cm) supplemented with LCLT (equivalent to 2 g of L-carnitine per day) or placebo (PL) for 21 d, provided muscle biopsies for AR determinations, then performed two RE protocols: one followed by water intake, and one followed by feeding (8 kcal·kg-1 body mass, consisting of 56% carbohydrate, 16% protein, and 28% fat). RE protocols were randomized and included serial blood draws and a 1-h post-RE biopsy. After a 7-d washout period, subjects crossed over, and all experimental procedures were repeated.

Results: LCLT supplementation upregulated (P < 0.05) preexercise AR content compared with PL (12.9 ± 5.9 vs 11.2 ± 4.0 au, respectively). RE increased (P < 0.05) AR content compared with pre-RE values in the PL trial only. Post-RE feeding significantly increased AR content compared with baseline and water trials for both LCLT and PL. Serum total testosterone concentrations were suppressed (P < 0.05) during feeding trials with respect to corresponding water and pre-RE values. Luteinizing hormone demonstrated subtle, yet significant changes in response to feeding and LCLT.

Conclusion: In summary, these data demonstrated that: 1) feeding after RE increased AR content, which may result in increased testosterone uptake, and thus enhanced luteinizing hormone secretion via feedback mechanisms; and 2) LCLT supplementation upregulated AR content, which may promote recovery from RE.

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