Underground Bodybuilding Militia

NSAIDs – (AB)USO DEGLI ANTI INFIAMMATORI NELLA PRATICA SPORTIVA.

 

I farmaci anti-infiammatori sono una delle categorie più comune ed abusata nel mondo sportivo attuale, soprattutto a livello professionistico. Gli estenuanti carichi di lavoro cui molti atleti sono sottoposti portano al cronicizzarsi di infiammazioni e dolori che rendono talvolta molto doloroso allenarsi. L’impellenza di competizioni, gare e la necessità di non fermarsi dagli allenamenti, portano parecchi sportivi ad abusare di questi farmaci (in seguito NSAIDs). La cosa preoccupante è il fatto che non siano solo gli sportivi ad abusarne, ma anche parecchie persone normali le quali, pur di non sentire il dolore, ne fanno sovente ricorso.

 

farmaci_antiinfiam NSAIDs – (AB)USO DEGLI ANTI INFIAMMATORI NELLA PRATICA SPORTIVA.

 

Spesso gli NSAIDs sono utilizzati per alleviare i DOMS conseguenti agli allenamenti, dolori che sono sintomo di danno tissutale  e quindi del lavoro svolto.

 

NSAIDs are thought to reduce pain primarily by inhibiting the activity of cyclooxygenase (COX), a family of enzymes that catalyze the conversion of arachidonic acid to proinflammatory prostanoids

 

Da qui si capisce il meccanismo di azione degli anti-infiammatori che agiscono inibendo gli enzimi COX che catalizzano la conversione dell’acido arachidonico in prostanoidi pro-infiammatori i quali sono in parte responsabili dell’indolenzimento da DOMS.

 

Prostanoids have been shown to be responsible, at least in part, for the soreness associated with DOMS. Studies show they promote inflammation and sensitize nocioceptors, thus heightening sensitivity to pain.

By blunting the synthesis of prostanoids, NSAIDs can conceivably reduce perceived discomfort post-exercise, allowing you to train hard and heavy day-in-day-out. And that should lead to better gains in size and strength, right?

Maybe not.

 

Ecco quindi che per ridurre l’indolenzimento ed i dolori alcuni ab(usano) dei NSAIDs per potersi allenare di più e/o più intensamente.

 

The acute post-exercise inflammatory process seems to play a role in muscular adaptations to resistance training. Prostanoids, in particular, have been shown to play a role in anabolic signaling. Specifically, they’re involved in stimulating pathways responsible for carrying out muscle protein synthesis

 

Fin qui nulla di grave se non fosse che i prostanoidi e i DOMS sono direttamente coinvolti nell’aumento della sintesi proteica a quanto pare: inibire i prostanoidi significa quindi andare a diminuire la sintesi stessa.

 

Considering that NSAIDs interfere with prostanoid production, it stands to reason that these drugs may also have a negative effect on muscle development. Indeed, early research showed this to be the case (Ref. T-Nation.com)

 

Purtroppo però si è visto in modelli animali come i NSAIDs inibiscano del 50% l’ipertrofia ed in modelli umani, malgrado una scienza non univoca, sembra diminuiscano la sintesi proteica dal 50 al 75%.

Il fattore più grave sembra essere comunque un altro e cioè che i COX inibiscano i prostanoidi i quali stimolano la proliferazione, differenziazione e fusione delle cellule satellite.

Sports Med. 2012 Dec 1;42(12):1017-28. doi: 10.2165/11635190-000000000-00000.

The use of nonsteroidal anti-inflammatory drugs for exercise-induced muscle damage: implications for skeletal muscle development.

Schoenfeld BJ.

Source

Department of Health Sciences, Program of Exercise Science, Lehman College, CUNY, Bronx, NY, USA.

Abstract

Exercise-induced muscle damage (EIMD) is a common condition resulting from a bout of vigorous exercise, particularly if the individual is unaccustomed to performance of the given movement. Symptoms of EIMD include delayed-onset muscle soreness (DOMS) and a loss of physical function. Nonsteroidal anti-inflammatory drugs (NSAIDs) are routinely prescribed post-exercise to alleviate these symptoms and restore normal physical function. Of potential concern for those who use NSAIDs to treat EIMD is the possibility that they may impair the adaptive response to exercise. Specifically, there is emerging evidence that the action of cyclo-oxygenase (COX) enzymes, and COX-2 in particular, are important and even necessary to achieve maximal skeletal muscle hypertrophy in response to functional overload. Given that NSAIDs exert their actions by blocking COX and thus suppressing prostaglandin production, a theoretical rationale exists whereby these drugs may have detrimental effects on muscle regeneration and supercompensation. Therefore, the purpose of this article is to extensively review the literature and evaluate the effects of NSAIDs on muscle growth and development. Based on current evidence, there is little reason to believe that the occasional use of NSAIDs will negatively affect muscle growth, although the efficacy for their use in alleviating inflammatory symptoms remains questionable. Evidence on the hypertrophic effects of the chronic use of NSAIDs is less clear. In those who are untrained, it does not appear that regular NSAID use will impede growth in the short term, and at least one study indicates that it may in fact have a positive impact. Given their reported impairment of satellite cell activity, however, longer-term NSAID use may well be detrimental, particularly in those who possess greater growth potential.

PMID:

Alla luce di questo studio e delle precedenti osservazioni appare chiaro come i NSAIDs non siano deleteri sul breve quanto sul lungo termine e come un loro impiego sia da intendersi solo come extrema ratio. Al loro posto si possono utilizzare sostanze naturali esenti da questi effetti collaterali come la curcumina.

Have your say